exRNAdisease

Entry Detail

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General Information

Database ID: exR0192561 RNA Name: hsa-miR-483-5p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 2134181 End Site(bp): 2134202 External Links: hsa-miR-483-5p

Disease Information

Disease Name: Epilepsy Disease Category: Nervous System Diseases MeSH ID: D004827 Type: Diseases Category/Nervous System Diseases Alias: Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID: GSE114697 Description: Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont) Experimental Design: Disease vs Control Case Disease Type: Epilepsy Case Disease SubType: NA Case Sample: Epilepsy Control Sample: Control Number of Case: 32 Number of Control: 16 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACTN4 chr19 38647649 38731589 + GATAD2B chr1 153789030 153923360 - MAPK1 chr22 21754500 21867680 - MLLT1 chr19 6210381 6279975 - NCLN chr19 3185563 3209575 + ORAI1 chr12 121626550 121642677 + PTMA chr2 231706895 231713541 + SOX4 chr6 21593751 21598619 + ZC3H4 chr19 47064187 47113776 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001134 chr20 21319681 21324846 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.4 chr16 68236845 68237667 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE114697 Sample Source: Blood Source Fraction: Plasma Platform: GPL22992 Method: RT-PCR array Num of detected RNA Type: 1 Num of detected RNAs of this Type: 78 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon). RNA library preparation protocol: 3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID: 30396857 Title: Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy Author: Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC Journal: EBioMedicine. 2018 Dec;38:127-141. Description: Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)