exRNAdisease

Entry Detail

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General Information

Database ID: exR0192563 RNA Name: hsa-miR-532-5p RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 50003167 End Site(bp): 50003188 External Links: hsa-miR-532-5p

Disease Information

Disease Name: Epilepsy Disease Category: Nervous System Diseases MeSH ID: D004827 Type: Diseases Category/Nervous System Diseases Alias: Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID: GSE114697 Description: Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont) Experimental Design: Disease vs Control Case Disease Type: Epilepsy Case Disease SubType: NA Case Sample: Epilepsy Control Sample: Control Number of Case: 32 Number of Control: 16 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AXL chr19 41219223 41261766 + CRIM1 chr2 36355778 36551135 + DCTN4 chr5 150708440 150759109 - LEPROTL1 chr8 30095408 30177208 + LUZP1 chr1 23084023 23177808 - MEX3A chr1 156072013 156082465 - PRRC1 chr5 127517609 127555089 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000787 chr17 54978779 54981849 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079781.5 chr7 97851688 97972985 - AL049796.1 chr1 93847174 93848939 + AP000553.1 chr22 21652270 21670237 + GAS5 chr1 173858559 173868882 - KCNQ1OT1 chr11 2608328 2699994 - RRN3P2 chr16 29074976 29116718 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE114697 Sample Source: Blood Source Fraction: Plasma Platform: GPL22992 Method: RT-PCR array Num of detected RNA Type: 1 Num of detected RNAs of this Type: 78 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon). RNA library preparation protocol: 3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID: 30396857 Title: Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy Author: Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC Journal: EBioMedicine. 2018 Dec;38:127-141. Description: Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)