exRNAdisease

Entry Detail

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General Information

Database ID: exR0192566 RNA Name: hsa-miR-660-5p RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 50013256 End Site(bp): 50013277 External Links: hsa-miR-660-5p

Disease Information

Disease Name: Epilepsy Disease Category: Nervous System Diseases MeSH ID: D004827 Type: Diseases Category/Nervous System Diseases Alias: Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID: GSE114697 Description: Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont) Experimental Design: Disease vs Control Case Disease Type: Epilepsy Case Disease SubType: NA Case Sample: Epilepsy Control Sample: Control Number of Case: 32 Number of Control: 16 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARF3 chr12 48935723 48957487 - ATXN7L3 chr17 44191805 44200113 - CALM1 chr14 90396502 90408268 + MEF2D chr1 156463727 156500779 - RSRC2 chr12 122503454 122527000 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000241 chr10 70847874 70856944 + hsa_circ_0001247 chr22 46125304 46136418 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AP005263.1 chr18 9102736 9254346 + DHRS4-AS1 chr14 23938219 24052555 - LINC00641 chr14 21200079 21206900 - SNHG16 chr17 76557764 76565348 + Display:

Experiment Detail

GEO ID: GSE114697 Sample Source: Blood Source Fraction: Plasma Platform: GPL22992 Method: RT-PCR array Num of detected RNA Type: 1 Num of detected RNAs of this Type: 78 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon). RNA library preparation protocol: 3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID: 30396857 Title: Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy Author: Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC Journal: EBioMedicine. 2018 Dec;38:127-141. Description: Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)