exRNAdisease

Entry Detail

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General Information

Database ID: exR0196379 RNA Name: hsa-miR-138-5p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 56858527 End Site(bp): 56858549 External Links: hsa-miR-138-5p

Disease Information

Disease Name: Disease Category: MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Alzheimer's Disease Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KRT80 chr12 52168996 52192014 - STX3 chr11 59713456 59805882 + SIN3A chr15 75369379 75455842 - RNH1 chr11 494512 507300 - ACTN4 chr19 38647649 38731589 + CDCA7L chr7 21900899 21945903 - COPS7B chr2 231781671 231809254 + LARP4B chr10 806914 931705 - GSK3A chr19 42230190 42242625 - GNAI2 chr3 50226292 50259362 + NINJ1 chr9 93121496 93134251 - IGF2BP1 chr17 48997385 49056145 + TFAP2A chr6 10393186 10419659 - FOXC1 chr6 1609915 1613897 + PATL1 chr11 59636716 59669037 - SRF chr6 43171269 43181506 + MAFG chr17 81918270 81927735 - AHDC1 chr1 27534035 27604431 - FOXP4 chr6 41546426 41602384 + HIF1AN chr10 100529072 100559998 + PRKACA chr19 14091688 14118084 - SMG1 chr16 18804853 18926454 - IQGAP1 chr15 90388242 90502239 + CTDSP1 chr2 218398256 218405941 + HMGA1 chr6 34236873 34246231 + KLF11 chr2 10042849 10054836 + ZHX2 chr8 122781655 122974510 + IQSEC1 chr3 12897043 13283281 - PLXNB2 chr22 50274979 50307646 - TRIB1 chr8 125430358 125438403 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000402 chr12 53670403 53671011 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.4 chr16 81030770 81031485 + AC144548.1 chr12 110387463 110445548 - AL137127.1 chr1 19072110 19075511 - H19 chr11 1995176 2001470 - MCF2L-AS1 chr13 112967484 112968824 - MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + PARD6G-AS1 chr18 80147924 80179839 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TUG1 chr22 30969245 30979395 + TFAP2A-AS1 chr6 10409340 10416446 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia