exRNAdisease

Entry Detail

General Information

Database ID:

exR0196542

RNA Name:

hsa-miR-21-5p

RNA Type:

miRNA

Chromosome:

chr17

Starnd:

+

Coordinate:

Start Site(bp):

59841273

End Site(bp):

59841294

External Links:

Disease Information

Disease Name:
Disease Category:
MeSH ID:
Type:
Alias:

Expression Detail

GEO ID:	GSE120584
Description:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:	Disease vs Control
Case Disease Type:	Alzheimer's Disease
Case Disease SubType:	NA
Case Sample:	Alzheimer's Disease
Control Sample:	Normal
Number of Case:	1021
Number of Control:	288
Number of Samples:	1309

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
KAZN	chr1	13892792	15118043	+
UBE2T	chr1	202331657	202341980	-
CLEC2D	chr12	9664969	9699553	+
EIF4A2	chr3	186783205	186789897	+
MGST1	chr12	16347142	16609259	+
POLE3	chr9	113407235	113410675	-
SOWAHC	chr2	109614364	109618990	+
OSER1	chr20	44195939	44210771	-
EXOC4	chr7	133253073	134066589	+
EDARADD	chr1	236348257	236502915	+
HNRNPA0	chr5	137745651	137754363	-
GPSM3	chr6	32190766	32195523	-
CTH	chr1	70411218	70439851	+
CITED2	chr6	139371807	139374648	-
MTREX	chr5	55307989	55425579	+
AP3D1	chr19	2100988	2164468	-
ELP2	chr18	36129444	36180557	+
HSPA4	chr5	133052013	133106449	+
RGS1	chr1	192575763	192580024	+
HSD17B4	chr5	119452473	119637199	+
ZFP36L1	chr14	68787660	68796253	-
HMGA1	chr6	34236873	34246231	+
EEF1B2	chr2	206159585	206162928	+
DYNC1H1	chr14	101964573	102056443	+
DUSP2	chr2	96143169	96145440	-
MCRS1	chr12	49556544	49568145	-
ATRX	chrX	77504878	77786233	-
ZADH2	chr18	75195113	75209139	-
PLIN2	chr9	19108375	19149290	-
TREX1	chr3	48465811	48467645	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001731	chr7	100731990	100738448	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC068768.1	chr12	123262060	123262402	+
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
OTUD6B-AS1	chr8	91059318	91070583	-
SNHG1	chr11	62851984	62855953	-
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE120584
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21263
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2532
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:	miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID:	30820472
Title:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:	Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:	Commun Biol. 2019 Feb 25;2:77.
Description:	we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia