exRNAdisease

Entry Detail

General Information

Database ID:

exR0197056

RNA Name:

hsa-miR-425-5p

RNA Type:

miRNA

Chromosome:

chr3

Starnd:

-

Coordinate:

Start Site(bp):

49020199

End Site(bp):

49020221

External Links:

Disease Information

Disease Name:
Disease Category:
MeSH ID:
Type:
Alias:

Expression Detail

GEO ID:	GSE120584
Description:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:	Disease vs Control
Case Disease Type:	Alzheimer's Disease
Case Disease SubType:	NA
Case Sample:	Alzheimer's Disease
Control Sample:	Normal
Number of Case:	1021
Number of Control:	288
Number of Samples:	1309

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ABL2	chr1	179099330	179229684	-
FOXC1	chr6	1609915	1613897	+
SH3PXD2A	chr10	103594027	103855543	-
SHC1	chr1	154962298	154974395	-
SLC16A2	chrX	74421493	74533917	+
TRIM22	chr11	5689697	5737089	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000591	chr15	41961025	41962156	+
hsa_circ_0000987	chr2	30748452	30756180	+
hsa_circ_0001151	chr20	35236117	35236221	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005034.3	chr2	75697583	75697996	+
AC120036.4	chr8	47190772	47193262	+
KCNQ1OT1	chr11	2608328	2699994	-
LINC01184	chr5	127939152	128083172	-
MALAT1	chr11	65497688	65506516	+
MCM3AP-AS1	chr21	46229196	46259390	+
NEAT1	chr11	65422774	65445540	+
SNHG7	chr9	136721366	136728184	-
SNHG8	chr4	118278709	118285316	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE120584
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21263
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2532
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:	miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID:	30820472
Title:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:	Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:	Commun Biol. 2019 Feb 25;2:77.
Description:	we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia