exRNAdisease

Entry Detail

General Information

Database ID:

exR0197152

RNA Name:

hsa-miR-4426

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

+

Coordinate:

Start Site(bp):

192716333

End Site(bp):

192716349

External Links:

Disease Information

Disease Name:
Disease Category:
MeSH ID:
Type:
Alias:

Expression Detail

GEO ID:	GSE120584
Description:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:	Disease vs Control
Case Disease Type:	Alzheimer's Disease
Case Disease SubType:	NA
Case Sample:	Alzheimer's Disease
Control Sample:	Normal
Number of Case:	1021
Number of Control:	288
Number of Samples:	1309

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
UFC1	chr1	161152776	161158856	+
NDUFA4	chr7	10931943	10940153	-
N4BP3	chr5	178113532	178126081	+
MTRNR2L11	chr1	237943724	237945275	-
RNF181	chr2	85595725	85597708	+
VMP1	chr17	59707192	59842255	+
DDB1	chr11	61299451	61342596	-
SAP18	chr13	21140514	21149084	+
DOCK6	chr19	11199295	11262524	-
NSMAF	chr8	58583508	58659853	-
APP	chr21	25880550	26171128	-
TMEM170A	chr16	75443054	75465497	-
TKFC	chr11	61333210	61353295	+
CTSZ	chr20	58995185	59007254	-
AL136454.1	chr1	192716132	192716653	+
TPT1	chr13	45333471	45341370	-
PTPN6	chr12	6946468	6961316	+
CAPNS1	chr19	36139953	36150353	+
CCNL2	chr1	1385711	1399335	-
RABGAP1L	chr1	174159410	174995308	+
RACK1	chr5	181236897	181248096	-
HMGN2	chr1	26472440	26476642	+
SEZ6L2	chr16	29871159	29899547	-
GAPDH	chr12	6534512	6538374	+
CD52	chr1	26317958	26320523	+
PCBP2	chr12	53452102	53481162	+
NDUFA11	chr19	5891276	5904006	-
REXO1	chr19	1815248	1848483	-
ZNF655	chr7	99558406	99576453	+
DCAF12	chr9	34086387	34127399	-

miRNA targets:

NA

circRNA targets:

NA

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC023509.1	chr12	53441741	53467528	+
AC105942.1	chr1	94927361	94963616	+

Display:

Experiment Detail

GEO ID:	GSE120584
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21263
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2532
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:	miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID:	30820472
Title:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:	Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:	Commun Biol. 2019 Feb 25;2:77.
Description:	we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia