exRNAdisease

Entry Detail

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General Information

Database ID: exR0197758 RNA Name: hsa-miR-543 RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101032033 End Site(bp): 101032054 External Links: hsa-miR-543

Disease Information

Disease Name: Disease Category: MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Alzheimer's Disease Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand FGFR1 chr8 38400215 38468834 - HSPA5 chr9 125234853 125241343 - ITSN1 chr21 33642400 33899861 + LIFR chr5 38474668 38608354 - PIK3C2A chr11 17077730 17207983 - TBC1D4 chr13 75283503 75482169 - TXLNA chr1 32179675 32198285 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0001368 chr3 183361267 183390272 + hsa_circ_0001860 chr9 37126308 37126939 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC144548.1 chr12 110387463 110445548 - AL031666.3 chr20 47348137 47349142 - AP005263.1 chr18 9102736 9254346 + MIR4458HG chr5 8450701 8486930 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia