exRNAdisease

Entry Detail

General Information

Database ID:

exR0197951

RNA Name:

hsa-miR-588

RNA Type:

miRNA

Chromosome:

chr6

Starnd:

+

Coordinate:

Start Site(bp):

126484646

End Site(bp):

126484666

External Links:

Disease Information

Disease Name:
Disease Category:
MeSH ID:
Type:
Alias:

Expression Detail

GEO ID:	GSE120584
Description:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:	Disease vs Control
Case Disease Type:	Alzheimer's Disease
Case Disease SubType:	NA
Case Sample:	Alzheimer's Disease
Control Sample:	Normal
Number of Case:	1021
Number of Control:	288
Number of Samples:	1309

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ADGRE5	chr19	14380501	14408725	+
ARHGDIA	chr17	81867721	81871378	-
EDEM3	chr1	184690237	184754907	-
EIF1AD	chr11	65996545	66002176	-
FURIN	chr15	90868588	90883458	+
GLIS2	chr16	4314761	4339597	+
NID1	chr1	235975830	236065109	-
NIP7	chr16	69337996	69343106	+
NT5DC3	chr12	103770453	103841234	-
STK40	chr1	36339624	36385896	-
TSPAN14	chr10	80454166	80533124	+
TUB	chr11	8019244	8106112	+
ZBTB39	chr12	56998836	57006546	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001025	chr2	69565029	69565697	-
hsa_circ_0000384	chr12	27867712	27877119	+
hsa_circ_0001247	chr22	46125304	46136418	+
hsa_circ_0000284	chr11	33307958	33309057	+
hsa_circ_0000126	chr1	150997086	150999803	+
hsa_circ_0000744	chr17	15968183	15971435	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007161.3	chr7	7640752	8004053	+
AL022311.1	chr22	37876148	37895563	+
AL359924.1	chr1	237862175	237928321	+
H19	chr11	1995176	2001470	-
MIR497HG	chr17	7015818	7019659	-
NEAT1	chr11	65422774	65445540	+
PINK1-AS	chr1	20642657	20652193	-
SNHG8	chr4	118278709	118285316	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE120584
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL21263
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2532
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:	miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID:	30820472
Title:	Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:	Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:	Commun Biol. 2019 Feb 25;2:77.
Description:	we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia