exRNAdisease

Entry Detail

---



General Information

Database ID: exR0198374 RNA Name: hsa-miR-6835-3p RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 34240714 End Site(bp): 34240736 External Links: hsa-miR-6835-3p

Disease Information

Disease Name: Disease Category: MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Alzheimer's Disease Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HMGA1 chr6 34236873 34246231 + SASH1 chr6 148272304 148552048 + HAPLN1 chr5 83637805 83720855 - MAMDC2 chr9 70043848 70226972 + PABPN1 chr14 23321289 23326185 + PTPRF chr1 43525187 43623666 + PUM1 chr1 30931506 31065991 - ZBTB32 chr19 35704558 35717038 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011815.1 chr18 35280867 35290201 - AC020978.7 chr16 68224713 68227734 + AC021078.1 chr5 149494314 149504670 - AL137129.1 chr14 61734138 61776260 + AL158825.2 chr9 75009828 75016036 - FGD5-AS1 chr3 14920347 14948424 - KCNQ1OT1 chr11 2608328 2699994 - MIR17HG chr13 91347820 91354579 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia