exRNAdisease

Entry Detail

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General Information

Database ID: exR0198990 RNA Name: hsa-miR-186-5p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 71067681 End Site(bp): 71067702 External Links: hsa-miR-186-5p

Disease Information

Disease Name: Dementia with Lewy Bodies Disease Category: Nervous System Diseases MeSH ID: D020961 Type: Diseases Category/Nervous System Diseases Alias: Lewy Body Disease//Diffuse Lewy Body Disease//Lewy Body Dementia//Cortical Lewy Body Disease//Lewy Body Disease, Cortical//Lewy Body Type Senile Dementia//Lewy Body Disease, Diffuse//Dementia, Lewy Body

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Dementia with Lewy Bodies Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDX3X chrX 41333284 41364472 + EP300 chr22 41092592 41180077 + GPRC5A chr12 12890782 12917937 + NRF1 chr7 129611720 129757082 + TACSTD2 chr1 58575433 58577252 - TMEM245 chr9 109015135 109119947 - TNFRSF21 chr6 47231532 47309905 - TNKS1BP1 chr11 57299638 57324952 - HMG20A chr15 77420412 77485607 + RNF139 chr8 124474738 124487914 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AC097634.1 chr3 71584943 71587409 + AC124798.1 chr11 17380649 17383531 + AC247036.1 chr14 106206603 106208571 + DLEU2 chr13 49956670 50125720 - DSCAM-AS1 chr21 40383083 40385358 + EBLN3P chr9 37079645 37090928 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG3 chr1 28505980 28510892 + SNHG7 chr9 136721366 136728184 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia