exRNAdisease

Entry Detail

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General Information

Database ID: exR0199751 RNA Name: hsa-miR-4485-3p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 10508277 End Site(bp): 10508296 External Links: hsa-miR-4485-3p

Disease Information

Disease Name: Dementia with Lewy Bodies Disease Category: Nervous System Diseases MeSH ID: D020961 Type: Diseases Category/Nervous System Diseases Alias: Lewy Body Disease//Diffuse Lewy Body Disease//Lewy Body Dementia//Cortical Lewy Body Disease//Lewy Body Disease, Cortical//Lewy Body Type Senile Dementia//Lewy Body Disease, Diffuse//Dementia, Lewy Body

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Dementia with Lewy Bodies Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C11orf24 chr11 68261338 68272001 - CDK4 chr12 57747727 57756013 - CKAP5 chr11 46743048 46846308 - CYB561A3 chr11 61348745 61362299 - SERINC1 chr6 122443351 122471807 - NES chr1 156668763 156677407 - NDUFB11 chrX 47142216 47145504 - FUBP1 chr1 77944055 77979110 - RPL27 chr17 42998273 43002959 + YEATS2 chr3 183697797 183812624 + CIRBP chr19 1259384 1274880 + DNM1 chr9 128191655 128255248 + MAP3K11 chr11 65597756 65615382 - RPL13 chr16 89560657 89566828 + EXOSC6 chr16 70246778 70251940 - SBF2 chr11 9778667 10294207 - HSPA8 chr11 123057489 123063230 - RPS27A chr2 55231903 55235853 + EIF3F chr11 7970251 8001862 + RNASEH2C chr11 65714005 65720818 - FAU chr11 65120630 65122177 - HSP90AB1 chr6 44246166 44253888 + RPS3 chr11 75399515 75422280 + NR3C1 chr5 143277931 143435512 - SPG11 chr15 44562696 44663678 - MTRNR2L6 chr7 142666272 142667718 + LGR4 chr11 27365961 27472790 - FRMD8 chr11 65386621 65413525 + CRTC3 chr15 90529923 90645345 + MTRNR2L12 chr3 96617188 96618236 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MALAT1 chr11 65497688 65506516 + XIST chrX 73820649 73852723 - AD000090.1 chr19 35557956 35581954 + LINC01002 chr19 198264 246544 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia