exRNAdisease

Entry Detail

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General Information

Database ID: exR0200139 RNA Name: hsa-miR-497-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 7017979 End Site(bp): 7017999 External Links: hsa-miR-497-5p

Disease Information

Disease Name: Dementia with Lewy Bodies Disease Category: Nervous System Diseases MeSH ID: D020961 Type: Diseases Category/Nervous System Diseases Alias: Lewy Body Disease//Diffuse Lewy Body Disease//Lewy Body Dementia//Cortical Lewy Body Disease//Lewy Body Disease, Cortical//Lewy Body Type Senile Dementia//Lewy Body Disease, Diffuse//Dementia, Lewy Body

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Dementia with Lewy Bodies Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARRDC4 chr15 97960703 97973833 + ZNF664 chr12 123971845 124015439 + ANKRD17 chr4 73073376 73258798 - ZBTB34 chr9 126860665 126885878 + PLAGL1 chr6 143940300 144064599 - PDE4A chr19 10416773 10469630 + ITPR1 chr3 4493345 4847840 + ARHGDIA chr17 81867721 81871378 - PRKACA chr19 14091688 14118084 - STEAP3 chr2 119223831 119265652 + AMER1 chrX 64185117 64205708 - PLPP6 chr9 4662294 4665258 + KMT2D chr12 49018975 49059774 - JARID2 chr6 15246069 15522042 + RGS3 chr9 113444731 113597743 + ANKRD13B chr17 29589769 29614761 + MINDY2 chr15 58771192 58861900 + TBRG1 chr11 124622836 124635926 + BIRC5 chr17 78214186 78225636 + PKN2 chr1 88684222 88836255 + GFPT1 chr2 69319769 69387254 - PIK3R1 chr5 68215756 68301821 + UNC119B chr12 120710458 120723640 + ATP6V0B chr1 43974487 43978295 + MAPK1IP1L chr14 55051647 55070194 + LITAF chr16 11547722 11636381 - TSC22D2 chr3 150408335 150466431 + MLEC chr12 120687149 120701859 + KDSR chr18 63327726 63367228 - AADAT chr4 170060222 170091699 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001263 chr3 5215701 5216099 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand FGD5-AS1 chr3 14920347 14948424 - AP000317.2 chr21 34073592 34360033 + MCM3AP-AS1 chr21 46229196 46259390 + AC079781.5 chr7 97851688 97972985 - MIR503HG chrX 134543119 134546642 - AC114980.1 chr5 93860669 93863825 - NUTM2A-AS1 chr10 87201647 87342612 - LINC02035 chr3 122886941 122892416 + MIR497HG chr17 7015818 7019659 - MZF1-AS1 chr19 58559129 58574797 + LINC01184 chr5 127939152 128083172 - AL031282.2 chr1 1702736 1737688 - SNHG16 chr17 76557764 76565348 + AC002470.2 chr22 20979462 20998121 + XIST chrX 73820649 73852723 - AL359924.1 chr1 237862175 237928321 + AC003092.1 chr7 94022833 94066661 + LINC00649 chr21 33915534 33977691 + HCG18 chr6 30286690 30327382 - LINC00662 chr19 27681072 27794005 - AL391244.1 chr1 1420245 1422691 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + MIR29B2CHG chr1 207801518 207879115 - AC021078.1 chr5 149494314 149504670 - AC020978.7 chr16 68224713 68227734 + AC009022.1 chr16 69976297 70065948 - NEAT1 chr11 65422774 65445540 + SNHG12 chr1 28578538 28583132 - SNHG1 chr11 62851984 62855953 - AC021092.1 chr19 44103007 44113183 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia