exRNAdisease

Entry Detail

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General Information

Database ID: exR0200664 RNA Name: hsa-miR-670-5p RNA Type: miRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 43559675 End Site(bp): 43559694 External Links: hsa-miR-670-5p

Disease Information

Disease Name: Dementia with Lewy Bodies Disease Category: Nervous System Diseases MeSH ID: D020961 Type: Diseases Category/Nervous System Diseases Alias: Lewy Body Disease//Diffuse Lewy Body Disease//Lewy Body Dementia//Cortical Lewy Body Disease//Lewy Body Disease, Cortical//Lewy Body Type Senile Dementia//Lewy Body Disease, Diffuse//Dementia, Lewy Body

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Dementia with Lewy Bodies Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000370 chr11 128628009 128651918 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001492 chr5 65284462 65290692 + hsa_circ_0000494 chr13 76134888 76143643 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + AC007780.1 chr17 68413623 68524949 + AC007952.4 chr17 19112000 19112636 - AC022167.2 chr16 8848105 8860456 + AL137782.1 chr13 75549773 75807120 + KCNQ1OT1 chr11 2608328 2699994 - LINC01783 chr1 16533886 16536172 - MALAT1 chr11 65497688 65506516 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia