exRNAdisease

Entry Detail

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General Information

Database ID: exR0201248 RNA Name: hsa-miR-103a-3p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 168560904 End Site(bp): 168560926 External Links: hsa-miR-103a-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RCCD1 chr15 90954870 90963125 + CA12 chr15 63321378 63381846 - AMER1 chrX 64185117 64205708 - PLPP6 chr9 4662294 4665258 + ERG28 chr14 75649791 75660876 - SCAMP4 chr19 1905372 1926013 + DPP3 chr11 66480013 66509657 + AC011455.2 chr19 38915404 38949855 - UBN1 chr16 4846665 4882401 + TMX2 chr11 57712593 57740973 + RNF157 chr17 76142465 76240493 - NAA60 chr16 3443649 3486953 + MRPS2 chr9 135499984 135504673 + TSPYL2 chrX 53082367 53088540 + KLHL21 chr1 6590724 6614607 - TUBA1B chr12 49127782 49131397 - STEAP3 chr2 119223831 119265652 + MRPL3 chr3 131462212 131502983 - STK16 chr2 219245455 219250337 + ABCF2 chr7 151207837 151227166 - RPS6KA3 chrX 20149911 20267519 - DCAF7 chr17 63550477 63594279 + CNN2 chr19 1026586 1039068 + SRPK1 chr6 35832966 35921342 - ZNF697 chr1 119619377 119648266 - LYSMD2 chr15 51723011 51751585 - PODXL chr7 131500262 131558217 - EBP chrX 48521799 48528716 + RPS14 chr5 150442635 150449739 - PKM chr15 72199029 72231822 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC003092.1 chr7 94022833 94066661 + AC018521.1 chr17 47945424 47981736 + AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC093297.2 chr5 44826076 44828592 + AL137127.1 chr1 19072110 19075511 - FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - LINC00294 chr11 33076149 33079454 + LINC00662 chr19 27681072 27794005 - LINC02035 chr3 122886941 122892416 + MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - NUTM2B-AS1 chr10 79661394 79826594 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TMEM147-AS1 chr19 35540738 35546029 - TTC28-AS1 chr22 27919376 28008581 + TTN-AS1 chr2 178521183 178779963 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia