exRNAdisease

Entry Detail

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General Information

Database ID: exR0201312 RNA Name: hsa-miR-124-3p RNA Type: miRNA Chromosome: chr8 Starnd: + Coordinate: Start Site(bp): 64379210 End Site(bp): 64379231 External Links: hsa-miR-124-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDH1 chr16 68737292 68835541 + MDK chr11 46380756 46383837 + TRAPPC10 chr21 44012309 44106552 + COL12A1 chr6 75084326 75206053 - RANBP10 chr16 67723070 67806652 - TSEN54 chr17 75516060 75524735 + ZCCHC24 chr10 79382325 79445624 - ASF1B chr19 14119512 14136613 - RPS10-NUDT3 chr6 34284887 34426071 - JAG1 chr20 10637684 10673999 - RPS6KA3 chrX 20149911 20267519 - CTDSP1 chr2 218398256 218405941 + NUDT3 chr6 34279679 34392669 - FAM102A chr9 127940582 127980989 - MMS22L chr6 97142161 97283217 - EPHB4 chr7 100802565 100827523 - ANGPTL2 chr9 127087348 127122635 - BLOC1S5-TXNDC5 chr6 7881522 8064364 - PAPSS2 chr10 87659613 87747705 + C20orf27 chr20 3753508 3768387 - MOB4 chr2 197515571 197553699 + SCAMP2 chr15 74843730 74873365 - CDKN2A chr9 21967753 21995301 - G3BP2 chr4 75642782 75724525 - ZSCAN22 chr19 58326994 58342332 + ANKRD52 chr12 56237807 56258384 - NFAT5 chr16 69565094 69704666 + CREB3L2 chr7 137874979 138002086 - CLASP1 chr2 121337776 121649587 - MLLT1 chr19 6210381 6279975 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001186 chr21 35475133 35475818 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008040.1 chr3 169939353 169966734 - AC069281.2 chr7 100572232 100578700 - AC084082.1 chr8 66112667 66126632 + FGD5-AS1 chr3 14920347 14948424 - KCNQ1OT1 chr11 2608328 2699994 - LINC00240 chr6 26956932 27059749 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + TMEM147-AS1 chr19 35540738 35546029 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia