exRNAdisease

Entry Detail

---



General Information

Database ID: exR0201391 RNA Name: hsa-miR-129-5p RNA Type: miRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 128207876 End Site(bp): 128207896 External Links: hsa-miR-129-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNRC6B chr22 40044817 40335808 + KRIT1 chr7 92198969 92246166 - SLC7A2 chr8 17497088 17570573 + TRIM71 chr3 32817997 32897824 + SHCBP1 chr16 46578591 46621379 - NEDD4 chr15 55826922 55993746 - ZNF605 chr12 132918306 132956306 - DDX18 chr2 117814691 117832377 + CPSF7 chr11 61402641 61430031 - RAD1 chr5 34905260 34918989 - UBN2 chr7 139230356 139308236 + DEGS1 chr1 224175756 224193441 + SEC62 chr3 169966635 169998373 + CRK chr17 1420689 1463162 - SLC35E1 chr19 16549831 16572415 - TRIM14 chr9 98069275 98119222 - ALDH5A1 chr6 24494867 24537207 + UFL1 chr6 96521595 96555276 + DUSP14 chr17 37489891 37513501 + WSB1 chr17 27294076 27315926 + DNAJC24 chr11 31369840 31432835 + CHURC1 chr14 64914361 64944591 + MLEC chr12 120687149 120701859 + CAMTA1 chr1 6785454 7769706 + THUMPD1 chr16 20702816 20742084 - EIF4A1 chr17 7572706 7579006 + ACER3 chr11 76860867 77026797 + TTPAL chr20 44475874 44494603 + PDS5A chr4 39822863 39977956 - FBXW7 chr4 152320544 152536092 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC097634.1 chr3 71584943 71587409 + AL049795.2 chr1 32170733 32176568 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - OIP5-AS1 chr15 41283990 41309737 + TBC1D3P1-DHX40P1 chr17 59962363 60018975 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia