exRNAdisease

Entry Detail

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General Information

Database ID: exR0201423 RNA Name: hsa-miR-1321 RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 85835832 End Site(bp): 85835849 External Links: hsa-miR-1321

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDAH1 chr1 85318481 85578363 - WASF2 chr1 27404230 27490167 - KDM5C chrX 53191321 53225422 - C19orf47 chr19 40319536 40348527 - UBE2Q1 chr1 154548577 154559028 - KLC2 chr11 66257294 66267860 + CBFA2T3 chr16 88874858 88977207 - ENSA chr1 150600851 150629612 - ZDHHC9 chrX 129803288 129843909 - MKNK2 chr19 2037465 2051244 - AKIRIN1 chr1 38991276 39006059 + NRF1 chr7 129611720 129757082 + REEP4 chr8 22138020 22141951 - BCL7A chr12 122019422 122062044 + CBX5 chr12 54230942 54280133 - SOX13 chr1 204073115 204127743 + LENG8 chr19 54448887 54462037 + CCND3 chr6 41934933 42050357 - STK35 chr20 2101827 2177038 + GPI chr19 34359480 34402413 + RCOR1 chr14 102592649 102730561 + ONECUT2 chr18 57435374 57491298 + SPTBN2 chr11 66685248 66729226 - WSB2 chr12 118032694 118062430 - ARID1A chr1 26693236 26782104 + HMGA1 chr6 34236873 34246231 + RARA chr17 40309180 40357643 + TP53 chr17 7661779 7687550 - TPP1 chr11 6612768 6619448 - SCD chr10 100347233 100364826 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022167.2 chr16 8848105 8860456 + AC069281.2 chr7 100572232 100578700 - AC124068.2 chr15 89335053 89336161 + AP000233.2 chr21 25095022 25103670 + HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + MIR22HG chr17 1711493 1717174 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TYMSOS chr18 630886 658340 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia