exRNAdisease

Entry Detail

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General Information

Database ID: exR0201507 RNA Name: hsa-miR-181b-5p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 124693725 End Site(bp): 124693747 External Links: hsa-miR-181b-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARRB2 chr17 4710596 4721499 + CDKN1B chr12 12715058 12722369 + COA4 chr11 73872667 73876901 - CPNE2 chr16 57092583 57148369 + ETV6 chr12 11649674 11895377 + GALNT10 chr5 154190730 154420984 + IGF2BP3 chr7 23310209 23470491 - LNX2 chr13 27545913 27620529 - NSMAF chr8 58583508 58659853 - PPP1R3C chr10 91628442 91633071 - TWISTNB chr7 19695461 19709037 - ZFP36L1 chr14 68787660 68796253 - CHMP6 chr17 80991598 81009517 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001550 chr5 167915606 167921655 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001361 chr3 171830241 171851336 + hsa_circ_0000931 chr19 38226804 38231095 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010442.1 chr5 466124 473098 - AC010655.4 chr7 128455840 128493859 + AC021078.1 chr5 149494314 149504670 - AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - AL049543.1 chr6 28587378 28591747 + KCNQ1OT1 chr11 2608328 2699994 - LINC00667 chr18 5237826 5290608 + MALAT1 chr11 65497688 65506516 + MIR4458HG chr5 8450701 8486930 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG5 chr6 85650491 85678932 - SNHG7 chr9 136721366 136728184 - THUMPD3-AS1 chr3 9349689 9398579 - XIST chrX 73820649 73852723 - ZSCAN16-AS1 chr6 28015122 28137293 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia