exRNAdisease

Entry Detail

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General Information

Database ID: exR0201528 RNA Name: hsa-miR-18a-5p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91350756 End Site(bp): 91350778 External Links: hsa-miR-18a-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PATZ1 chr22 31325804 31346346 - TUBA4A chr2 219249710 219278170 - SURF4 chr9 133361450 133376166 - DDX5 chr17 64498254 64508199 - SND1 chr7 127652194 128092609 + HIF1AN chr10 100529072 100559998 + SIK2 chr11 111602449 111730855 + FKBP1A chr20 1368978 1393172 - USP10 chr16 84699978 84779922 + PARL chr3 183829271 183884933 - ASF1B chr19 14119512 14136613 - PRPF38B chr1 108692310 108702928 + ADAT2 chr6 143422832 143450695 - ZNF12 chr7 6688433 6706947 - DNAJC9 chr10 73183362 73247255 - AC131160.1 chr3 183815568 183884889 - ACSS2 chr20 34872146 34927962 + MRPS18A chr6 43671303 43687791 - XRCC6 chr22 41621119 41664048 + ROMO1 chr20 35699272 35700984 + PEX5 chr12 7188685 7218574 + NDUFV2 chr18 9102630 9134345 + UBE2Z chr17 48908407 48929056 + NOP58 chr2 202265736 202303661 + RNF4 chr4 2462220 2625320 + CHD1 chr5 98853985 98928957 - ATP2B1 chr12 89588049 89709300 - SLC41A1 chr1 205789094 205813748 - NCDN chr1 35557473 35567274 + HMGCS1 chr5 43287470 43313512 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000921 chr19 30476129 30477324 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC073896.4 chr12 56162359 56190284 - AC093010.3 chr3 114314501 114329714 - AC145207.5 chr17 81878425 81881106 - AL162171.3 chr14 88589231 88592408 + AP005263.1 chr18 9102736 9254346 + CASC2 chr10 118046279 118210158 + GAS5 chr1 173858559 173868882 - NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - SNHG15 chr7 44983023 44986961 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia