exRNAdisease

Entry Detail

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General Information

Database ID: exR0201630 RNA Name: hsa-miR-217-5p RNA Type: miRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 55983020 End Site(bp): 55983042 External Links: hsa-miR-217-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PNPO chr17 47941506 47949308 + SLC26A2 chr5 149960758 149993455 + ICAM1 chr19 10271093 10286615 + ARHGAP11A chr15 32615144 32639941 + SFXN1 chr5 175477062 175529742 + EIF1AD chr11 65996545 66002176 - KPNA4 chr3 160495007 160565571 - LYSMD4 chr15 99715697 99733561 - AXL chr19 41219223 41261766 + OPA3 chr19 45527427 45602212 - IRF4 chr6 391752 411443 + SLC25A32 chr8 103398635 103415189 - UBE2G1 chr17 4269259 4366628 - MMD chr17 55392622 55421924 - CDH1 chr16 68737292 68835541 + ICK chr6 53001279 53061802 - PARD6B chr20 50731580 50756795 + GOLGA3 chr12 132768914 132829078 - MET chr7 116672196 116798386 + ACER2 chr9 19409009 19452505 + PSKH1 chr16 67893254 67929676 + EIF2S3 chrX 24054946 24078810 + VHL chr3 10141008 10152220 + DDX3X chrX 41333284 41364472 + ZNF587 chr19 57849859 57865117 + TSEN54 chr17 75516060 75524735 + CNN2 chr19 1026586 1039068 + CHD9 chr16 53055033 53329150 + ERLIN1 chr10 100150094 100186033 - TFPI chr2 187464230 187565760 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand ADAMTSL4-AS1 chr1 150560202 150574552 - AP000553.1 chr22 21652270 21670237 + GAS5 chr1 173858559 173868882 - LINC01578 chr15 92819540 92899701 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia