exRNAdisease

Entry Detail

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General Information

Database ID: exR0201680 RNA Name: hsa-miR-27b-3p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 95085505 End Site(bp): 95085525 External Links: hsa-miR-27b-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NUAK1 chr12 106063340 106140033 - IDS chrX 149476988 149521096 - AEN chr15 88621337 88632281 + RTL10 chr22 19846138 19854896 - SOX11 chr2 5692384 5701385 + KCNK1 chr1 233614106 233672514 + ALDH3A2 chr17 19648136 19685760 + GIPC1 chr19 14477760 14496149 - LASP1 chr17 38869859 38921770 + LARP4B chr10 806914 931705 - DCTN4 chr5 150708440 150759109 - TMX4 chr20 7977346 8019805 - B4GALT3 chr1 161171310 161177968 - GLTP chr12 109850945 109880541 - PLK2 chr5 58453982 58460139 - URGCP chr7 43875894 43926411 - ONECUT2 chr18 57435374 57491298 + ACER3 chr11 76860867 77026797 + PRKX chrX 3604340 3713649 - LGALS8 chr1 236518000 236552981 + CDR2 chr16 22345936 22437165 - NRBP1 chr2 27427790 27442259 + CANX chr5 179678628 179731641 + IRF4 chr6 391752 411443 + INO80D chr2 205993721 206086303 - PPP1CC chr12 110719680 110742939 - TTYH3 chr7 2631986 2664802 + IGF2BP3 chr7 23310209 23470491 - KPNA6 chr1 32108056 32176563 + STRBP chr9 123109500 123268586 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0000942 chr19 46020920 46021352 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010980.2 chr2 222317242 222318653 - AC021092.1 chr19 44103007 44113183 - AC022150.4 chr19 52650437 52653284 - AC093010.3 chr3 114314501 114329714 - AL050341.2 chr1 40256427 40257967 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - LINC02381 chr12 54126082 54147485 + NEAT1 chr11 65422774 65445540 + SDCBP2-AS1 chr20 1325405 1378735 + SNHG22 chr18 49814023 49851059 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia