exRNAdisease

Entry Detail

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General Information

Database ID: exR0201683 RNA Name: hsa-miR-28-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 188688794 End Site(bp): 188688815 External Links: hsa-miR-28-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RTL8A chrX 135050932 135052196 - LYPD3 chr19 43460787 43465608 - RGMA chr15 93035273 93089204 - GLYR1 chr16 4803203 4847288 - E2F6 chr2 11444375 11466177 - PTPN23 chr3 47381011 47413435 + KCTD5 chr16 2682523 2709030 + GPCPD1 chr20 5544439 5611006 - ENSA chr1 150600851 150629612 - AMOTL2 chr3 134355874 134375479 - SSR2 chr1 156009048 156020951 - FAM102A chr9 127940582 127980989 - N4BP1 chr16 48538726 48620148 - CPSF2 chr14 92121969 92172145 + EZH1 chr17 42700275 42745049 - KIAA1522 chr1 32741830 32774970 + LONRF2 chr2 100271875 100322501 - MAPK1 chr22 21754500 21867680 - LASP1 chr17 38869859 38921770 + SMYD1 chr2 88067825 88113384 + NAPA chr19 47487637 47515091 - URGCP chr7 43875894 43926411 - SMG5 chr1 156249224 156282825 - DYRK1A chr21 37365573 37526358 + RTL8B chrX 135020513 135022542 - SLC31A1 chr9 113221544 113264492 + SEH1L chr18 12947133 12987536 + ZBTB7B chr1 155002630 155018522 + TUB chr11 8019244 8106112 + TEX261 chr2 70985942 70994873 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009065.4 chr16 2119207 2120248 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC118758.3 chr7 56809214 56848800 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia