exRNAdisease

Entry Detail

---



General Information

Database ID: exR0201690 RNA Name: hsa-miR-299-3p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101023832 End Site(bp): 101023853 External Links: hsa-miR-299-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFF4 chr5 132875395 132963634 - AK2 chr1 33007940 33080996 - AP3M1 chr10 74120255 74151063 - ARCN1 chr11 118572390 118603033 + CASP2 chr7 143288215 143307696 + CMIP chr16 81445170 81711762 + COL4A2 chr13 110305812 110513209 + CORO2B chr15 68578993 68727806 + DHX33 chr17 5440917 5468982 - DNAJC9 chr10 73183362 73247255 - E2F6 chr2 11444375 11466177 - FHL2 chr2 105357712 105438513 - GLCCI1 chr7 7968796 8094272 + LY6E chr8 143017982 143023832 + MAP3K14 chr17 45263119 45317029 - MAP3K2 chr2 127298730 127388465 - MAP3K20 chr2 173075435 173268015 + MBNL1 chr3 152243828 152465780 + MPZL1 chr1 167721192 167791919 + PCGF3 chr4 705748 770640 + PGK1 chrX 77910739 78129295 + PTPRJ chr11 47980558 48170841 + RAB8A chr19 16111889 16134234 + SAMD4B chr19 39342396 39385710 + SORBS3 chr8 22544986 22575788 + TCF3 chr19 1609290 1652615 - TMEM127 chr2 96248516 96265994 - USP37 chr2 218450251 218568351 - ZIC1 chr3 147393422 147510293 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC135048.1 chr16 30948386 30956511 + DSCAM-AS1 chr21 40383083 40385358 + KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia