exRNAdisease

Entry Detail

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General Information

Database ID: exR0201697 RNA Name: hsa-miR-29c-3p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 207801865 End Site(bp): 207801886 External Links: hsa-miR-29c-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AMER1 chrX 64185117 64205708 - APH1A chr1 150265399 150269580 - APP chr21 25880550 26171128 - BCL11A chr2 60450520 60554467 - BIRC5 chr17 78214186 78225636 + C1QTNF6 chr22 37180166 37199385 - CALU chr7 128739292 128773400 + CREG1 chr1 167529117 167553805 - FASN chr17 82078338 82098294 - FBXO10 chr9 37510892 37576380 - GATAD2B chr1 153789030 153923360 - KLHDC3 chr6 43014103 43021298 + KLHL28 chr14 44924319 45042322 - KMT5C chr19 55339853 55348121 + NASP chr1 45583846 45618904 + NMI chr2 151270470 151289894 - PER3 chr1 7784320 7845177 + RNF138 chr18 32091874 32131561 + SH3GLB1 chr1 86704570 86748184 + SP1 chr12 53380176 53416446 + CTSS chr1 150730188 150765792 - KDM5B chr1 202724495 202808487 - NREP chr5 111662621 111997464 - RINT1 chr7 105532169 105567677 + RPL13 chr16 89560657 89566828 + ZNF318 chr6 43307134 43369647 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007036.3 chr7 30157531 30159534 + AC012146.1 chr17 5111468 5115004 + AC018521.1 chr17 47945424 47981736 + AL137129.1 chr14 61734138 61776260 + AL355488.1 chr1 110370154 110373003 + AL391244.1 chr1 1420245 1422691 + AP001432.1 chr21 37221419 37237744 + H19 chr11 1995176 2001470 - MIR4458HG chr5 8450701 8486930 + MIR497HG chr17 7015818 7019659 - MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia