exRNAdisease

Entry Detail

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General Information

Database ID: exR0201700 RNA Name: hsa-miR-301a-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 59151149 End Site(bp): 59151171 External Links: hsa-miR-301a-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDH3A2 chr17 19648136 19685760 + TNFRSF1B chr1 12166991 12209228 + CAMTA1 chr1 6785454 7769706 + CPEB4 chr5 173888349 173961980 + ZDHHC7 chr16 84974181 85011535 - STARD13 chr13 33103137 33350630 - APCDD1 chr18 10454635 10489949 + HABP4 chr9 96450169 96491336 + TBC1D5 chr3 17157162 18444817 - ZNF12 chr7 6688433 6706947 - PTEN chr10 87863625 87971930 + NPTX1 chr17 80466834 80477843 - APOL6 chr22 35648446 35668404 + CD151 chr11 832887 839831 + PPP1R9A chr7 94907202 95296415 + KIAA0232 chr4 6781375 6884170 + ZNF594 chr17 5179535 5191868 - LIPA chr10 89213569 89414557 - LYSMD2 chr15 51723011 51751585 - MLPH chr2 237485428 237555322 + EMP1 chr12 13196723 13219941 + KLF4 chr9 107484852 107490482 - RTN4 chr2 54972187 55112621 - SCAF11 chr12 45919131 45992120 - RNF11 chr1 51236273 51273447 + XXYLT1 chr3 195068284 195271159 - SHANK2 chr11 70467856 71252577 - NSD2 chr4 1871393 1982207 + SLC7A5 chr16 87830023 87869507 - MTMR9 chr8 11284816 11328146 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC021092.1 chr19 44103007 44113183 - AC135050.6 chr16 31122235 31124064 + AC234582.1 chr1 155195004 155205495 + AL031595.3 chr22 44139365 44153626 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - AL603839.3 chr1 40493157 40508661 - CKMT2-AS1 chr5 81201341 81301565 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia