exRNAdisease

Entry Detail

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General Information

Database ID: exR0201876 RNA Name: hsa-miR-330-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 45639009 End Site(bp): 45639031 External Links: hsa-miR-330-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANP32B chr9 97983341 98015943 + ATRX chrX 77504878 77786233 - BCL2L11 chr2 111119378 111168445 + CBX2 chr17 79778148 79787983 + CCSER2 chr10 84328586 84518521 + CRCP chr7 66114604 66154568 + DAG1 chr3 49468703 49535618 + ERLIN1 chr10 100150094 100186033 - GNAI2 chr3 50226292 50259362 + HNRNPAB chr5 178204533 178211163 + MRFAP1 chr4 6640091 6642745 + MTMR12 chr5 32226994 32312987 - NPAT chr11 108157215 108222638 - PFN1 chr17 4945652 4949061 - PKN2 chr1 88684222 88836255 + RAB10 chr2 26034084 26137454 + SNX27 chr1 151612006 151699091 + TNKS chr8 9555912 9782346 + TOMM34 chr20 44942130 44960397 - TRIM25 chr17 56836387 56914080 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.7 chr16 68224713 68227734 + AC079781.5 chr7 97851688 97972985 - AC124045.1 chr3 44667412 44669364 + AC125257.1 chr17 41848518 41851447 - AL132655.1 chr20 58833809 58836529 - AL137129.1 chr14 61734138 61776260 + AL157392.3 chr10 13631143 13668445 + FGD5-AS1 chr3 14920347 14948424 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia