exRNAdisease

Entry Detail

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General Information

Database ID: exR0201877 RNA Name: hsa-miR-330-5p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 45639049 End Site(bp): 45639070 External Links: hsa-miR-330-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZNF3 chr7 100064033 100082548 - ALDH5A1 chr6 24494867 24537207 + ENG chr9 127815012 127854756 - NEMP1 chr12 57055643 57088063 - STX3 chr11 59713456 59805882 + RTL10 chr22 19846138 19854896 - GIPC1 chr19 14477760 14496149 - ANKRD13B chr17 29589769 29614761 + UBE4A chr11 118359585 118399211 + MARK2 chr11 63838928 63911019 + ATXN1 chr6 16299112 16761491 - NME4 chr16 396725 410367 + TMEM127 chr2 96248516 96265994 - PDXK chr21 43719094 43762307 + GUCD1 chr22 24540423 24555935 - MTG2 chr20 62183029 62203568 + VLDLR chr9 2621787 2660056 + EIF4A1 chr17 7572706 7579006 + GIGYF1 chr7 100679507 100694037 - DOLPP1 chr9 129081111 129090438 + SMAD3 chr15 67063763 67195169 + MAP4 chr3 47850690 48089272 - ABL1 chr9 130713016 130887675 + PAQR4 chr16 2969270 2973484 + NR4A2 chr2 156324437 156342348 - CRTC3 chr15 90529923 90645345 + PPME1 chr11 74171267 74254703 + GOSR2 chr17 46923075 46975524 + MYO1C chr17 1464186 1492686 - AGTRAP chr1 11736084 11754802 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000128 chr1 151139409 151139890 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001727 chr7 99621041 99621930 + hsa_circ_0001865 chr9 86292641 86293514 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC144548.1 chr12 110387463 110445548 - AL355075.4 chr14 20343048 20343685 - AL359924.1 chr1 237862175 237928321 + AP000553.1 chr22 21652270 21670237 + KCNQ1OT1 chr11 2608328 2699994 - MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - SNHG3 chr1 28505980 28510892 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia