exRNAdisease

Entry Detail

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General Information

Database ID: exR0201911 RNA Name: hsa-miR-3609 RNA Type: miRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 98881700 End Site(bp): 98881723 External Links: hsa-miR-3609

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IGF2 chr11 2129112 2141238 - MAP3K7 chr6 90513573 90587072 - MYH9 chr22 36281277 36388067 - PIK3C2A chr11 17077730 17207983 - CCNY chr10 35247025 35572669 + CCT2 chr12 69585426 69601570 + GPRIN3 chr4 89236383 89307800 - ING5 chr2 241687085 241729478 + NUP98 chr11 3671083 3797792 - P2RX5-TAX1BP3 chr17 3663063 3696194 - PBX2 chr6 32184733 32190202 - RPLP0 chr12 120196699 120201235 - TAX1BP3 chr17 3662895 3668679 - WDR74 chr11 62832342 62841809 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL356488.2 chr1 109100193 109100619 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia