exRNAdisease

Entry Detail

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General Information

Database ID: exR0201912 RNA Name: hsa-miR-361-3p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 85903641 End Site(bp): 85903663 External Links: hsa-miR-361-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADD1 chr4 2843857 2930076 + ATP2A3 chr17 3923870 3964464 - C6orf89 chr6 36871870 36928964 + CBX2 chr17 79778148 79787983 + CCDC88C chr14 91271323 91417844 - CDC25B chr20 3786772 3806121 + CTDSP2 chr12 57819927 57846729 - CTSB chr8 11842524 11869448 - EGR1 chr5 138465479 138469303 + FOXP4 chr6 41546426 41602384 + HYOU1 chr11 119044188 119057227 - IGF2BP1 chr17 48997385 49056145 + NACC1 chr19 13116862 13141147 + NPTN chr15 73560014 73634134 - PRMT1 chr19 49675786 49689029 + SH2B1 chr16 28846600 28874212 + SPTBN2 chr11 66685248 66729226 - TNFAIP3 chr6 137867214 137883312 + UBTF chr17 44205033 44221626 - VCL chr10 73995193 74121363 + ZBTB7A chr19 4043303 4066899 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000921 chr19 30476129 30477324 + hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC092127.1 chr16 85592266 85595720 + KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia