exRNAdisease

Entry Detail

---



General Information

Database ID: exR0201929 RNA Name: hsa-miR-362-3p RNA Type: miRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 50009005 End Site(bp): 50009026 External Links: hsa-miR-362-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PTPRJ chr11 47980558 48170841 + KIAA0232 chr4 6781375 6884170 + USF2 chr19 35268962 35279821 + BLCAP chr20 37492472 37527931 - AC009133.6 chr16 29812261 29820092 + WDR82 chr3 52254434 52288020 - PIP4K2B chr17 38765689 38800126 - ARF3 chr12 48935723 48957487 - TRPS1 chr8 115408496 115809673 - UBTF chr17 44205033 44221626 - FAM126B chr2 200973718 201071671 - ZBTB2 chr6 151364115 151391559 - TNFRSF21 chr6 47231532 47309905 - RUNX1 chr21 34787801 36004667 - MTPN chr7 135926760 135977359 - SERTAD3 chr19 40440844 40444335 - DCBLD2 chr3 98795941 98901695 - ATP8B1 chr18 57646426 57803315 - SLF2 chr10 100912963 100965134 + SDCBP chr8 58552924 58582859 + TNFRSF1B chr1 12166991 12209228 + COQ8A chr1 226897536 226987545 + DNAJB9 chr7 108569867 108574850 + VAMP2 chr17 8159149 8163546 - SIK1B chr21 6111131 6123778 + SMAP2 chr1 40344850 40423326 + FAM219A chr9 34398184 34458570 - CA12 chr15 63321378 63381846 - CALM1 chr14 90396502 90408268 + AKAP11 chr13 42272152 42323261 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001588 chr6 26204839 26205043 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - KCNQ1OT1 chr11 2608328 2699994 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + SCARNA9 chr11 93721513 93721865 + SNHG25 chr17 64145970 64146476 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia