exRNAdisease

Entry Detail

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General Information

Database ID: exR0201941 RNA Name: hsa-miR-3648 RNA Type: miRNA Chromosome: chr21 Starnd: + Coordinate: Start Site(bp): 8987026 End Site(bp): 8987046 External Links: hsa-miR-3648

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MT-CO2 chrMT 7586 8269 + THAP7 chr22 20999104 21002196 - CERS4 chr19 8206736 8262421 + ARL8B chr3 5122245 5180912 + EEF1G chr11 62559596 62574086 - FNBP4 chr11 47716494 47767443 - PTGES3 chr12 56663341 56688408 - AP002990.1 chr11 62559603 62591531 - PTCH2 chr1 44819844 44843253 - MAPK9 chr5 180233143 180292099 - ACTG1 chr17 81509971 81523847 - ECPAS chr9 111360692 111484745 - RNF126 chr19 647526 663233 - SF3A2 chr19 2236824 2248655 + TPT1 chr13 45333471 45341370 - AKIRIN2 chr6 87674860 87702233 - LZTS3 chr20 3162617 3173592 - AL133352.1 chr10 100505628 100529881 - ATP6V0A2 chr12 123712353 123761755 + SET chr9 128683424 128696400 + SH3GLB2 chr9 129007036 129028303 - PAM16 chr16 4331549 4355607 - LRRC45 chr17 82023305 82031151 + SRRM2 chr16 2752626 2772538 + NDUFB8 chr10 100523740 100530000 - GAPDH chr12 6534512 6538374 + CORO7-PAM16 chr16 4340251 4420494 - SKI chr1 2228319 2310213 + SSR2 chr1 156009048 156020951 - ARRDC4 chr15 97960703 97973833 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia