exRNAdisease

Entry Detail

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General Information

Database ID: exR0201945 RNA Name: hsa-miR-3652 RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 103930425 End Site(bp): 103930442 External Links: hsa-miR-3652

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP5MC3 chr2 175176258 175184607 - GANAB chr11 62624826 62646726 - HDLBP chr2 241227264 241317061 - PGRMC1 chrX 119236245 119244466 + PTMA chr2 231706895 231713541 + RAB15 chr14 64945814 64973226 - AC099811.2 chr17 42119674 42154916 - AP2A1 chr19 49766968 49807113 + AP2M1 chr3 184174689 184184091 + ARHGAP33 chr19 35774532 35788822 + BDNF chr11 27654893 27722058 - BRI3 chr7 98252379 98310441 + CCT6A chr7 56051685 56063989 + FKBP8 chr19 18531751 18544077 - GATC chr12 120446444 120463749 + GDF11 chr12 55743122 55757264 + HLA-DRA chr6 32439878 32445046 + HSP90B1 chr12 103930107 103953645 + MIB2 chr1 1615415 1630610 + RAB5C chr17 42124976 42155044 - SF3A2 chr19 2236824 2248655 + SFPQ chr1 35176378 35193145 - WASF1 chr6 110099819 110180004 - WBP11 chr12 14784582 14803486 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022819.1 chr15 99157231 99161140 - AL591742.2 chr1 114032393 114034511 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia