exRNAdisease

Entry Detail

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General Information

Database ID: exR0202194 RNA Name: hsa-miR-432-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 100884496 End Site(bp): 100884518 External Links: hsa-miR-432-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL1 chr9 130713016 130887675 + ANXA2 chr15 60347134 60402883 - ATP5MC3 chr2 175176258 175184607 - BLCAP chr20 37492472 37527931 - CA12 chr15 63321378 63381846 - CALM1 chr14 90396502 90408268 + CELSR2 chr1 109249539 109275751 + CHTF8 chr16 69118010 69132578 - DNAJC13 chr3 132417502 132539032 + EPB41 chr1 28887091 29120046 + FADS2 chr11 61792980 61867354 + FN1 chr2 215360440 215436073 - GGA3 chr17 75236599 75262363 - GNAI2 chr3 50226292 50259362 + HMBOX1 chr8 28890395 29064764 + IGF1R chr15 98648539 98964530 + IPO9 chr1 201829149 201884291 + KDM3B chr5 138352685 138437028 + MFHAS1 chr8 8783354 8893630 - NAPEPLD chr7 103099776 103149560 - PHC3 chr3 170086732 170181749 - PRELID3B chr20 59033145 59042809 - PTCD3 chr2 86106223 86142157 + RASA1 chr5 87267883 87391931 + SETD7 chr4 139495941 139606699 - STAMBP chr2 73828916 73873659 + TMEM63A chr1 225845536 225882380 - TOB2 chr22 41433494 41446801 - ZBTB34 chr9 126860665 126885878 + ZNF12 chr7 6688433 6706947 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001349 chr3 152132729 152150709 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC016876.2 chr17 7581964 7584086 - AC068768.1 chr12 123262060 123262402 + AC239868.1 chr1 149861271 149862504 + KCNQ1OT1 chr11 2608328 2699994 - LINC00649 chr21 33915534 33977691 + NEAT1 chr11 65422774 65445540 + PCBP2-OT1 chr12 53464468 53465057 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia