exRNAdisease

Entry Detail

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General Information

Database ID: exR0202301 RNA Name: hsa-miR-449b-5p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 55170706 End Site(bp): 55170727 External Links: hsa-miR-449b-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MID1 chrX 10445310 10833654 - JPH1 chr8 74234700 74321540 - TAOK1 chr17 29390464 29551904 + DEDD2 chr19 42198598 42220140 - PTPRJ chr11 47980558 48170841 + GNA12 chr7 2728105 2844308 - HNRNPUL1 chr19 41262496 41307787 + ZNF623 chr8 143636013 143656418 + SUPT6H chr17 28662198 28702679 + NCOR1 chr17 16029157 16218185 - IGSF3 chr1 116574399 116667755 - ANKRD52 chr12 56237807 56258384 - ESS2 chr22 19130279 19144684 - TNRC6B chr22 40044817 40335808 + ZIC5 chr13 99962964 99971909 - JRK chr8 142657460 142681968 - GATAD2B chr1 153789030 153923360 - ATXN7L3 chr17 44191805 44200113 - AMER1 chrX 64185117 64205708 - STK38L chr12 27243968 27325959 + SH3PXD2A chr10 103594027 103855543 - CD151 chr11 832887 839831 + NPTX1 chr17 80466834 80477843 - MYCN chr2 15940550 15947007 + NDST1 chr5 150485818 150558211 + TMEM109 chr11 60914158 60923443 + ERGIC1 chr5 172834251 172952683 + RTL8B chrX 135020513 135022542 - FGFRL1 chr4 1009936 1026898 + IL2RB chr22 37125843 37175054 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0001865 chr9 86292641 86293514 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + AC116913.1 chr15 66488658 66492109 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC00665 chr19 36313067 36331770 - NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia