exRNAdisease

Entry Detail

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General Information

Database ID: exR0202339 RNA Name: hsa-miR-4524a-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 69099606 End Site(bp): 69099627 External Links: hsa-miR-4524a-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001159 chr20 40161688 40179999 - hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0000826 chr18 9182379 9221997 + hsa_circ_0001263 chr3 5215701 5216099 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC009022.1 chr16 69976297 70065948 - AC021078.1 chr5 149494314 149504670 - AC079781.5 chr7 97851688 97972985 - AC114980.1 chr5 93860669 93863825 - AL049840.4 chr14 103694516 103695050 - AP000317.2 chr21 34073592 34360033 + KCNQ1OT1 chr11 2608328 2699994 - LINC00662 chr19 27681072 27794005 - LINC01184 chr5 127939152 128083172 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NUTM2A-AS1 chr10 87201647 87342612 - NUTM2B-AS1 chr10 79661394 79826594 - OIP5-AS1 chr15 41283990 41309737 + RRN3P2 chr16 29074976 29116718 + SNHG1 chr11 62851984 62855953 - SNHG16 chr17 76557764 76565348 + ZSCAN16-AS1 chr6 28015122 28137293 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia