exRNAdisease

Entry Detail

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General Information

Database ID: exR0202486 RNA Name: hsa-miR-4709-5p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74480175 End Site(bp): 74480196 External Links: hsa-miR-4709-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + CBX2 chr17 79778148 79787983 + CTNND1 chr11 57753243 57819546 + DNAJB6 chr7 157335381 157417439 + ERP29 chr12 112013348 112023449 + LAMC1 chr1 183023420 183145592 + ARID4B chr1 235131634 235328219 - CLSTN3 chr12 7129698 7158945 + DHX16 chr6 30653119 30673006 - GFM2 chr5 74721206 74767147 - HNRNPL chr19 38836388 38852347 - HOXB13 chr17 48724763 48729178 - HSP90AA1 chr14 102080738 102139699 - IDH1 chr2 208236227 208266074 - IREB2 chr15 78437431 78501453 + MKKS chr20 10401009 10434222 - MSH3 chr5 80654652 80876815 + NPC2 chr14 74476192 74494177 - PABPC1 chr8 100685816 100722809 - PODXL chr7 131500262 131558217 - PRDX5 chr11 64318121 64321811 + SCAF8 chr6 154733325 154834244 + TIAM2 chr6 154832697 155257723 + UGP2 chr2 63840940 63891562 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005479.1 chr14 74474007 74474864 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia