exRNAdisease

Entry Detail

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General Information

Database ID: exR0202647 RNA Name: hsa-miR-485-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101055427 End Site(bp): 101055448 External Links: hsa-miR-485-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZDHHC18 chr1 26826688 26857604 + ZNF106 chr15 42412823 42491141 - IFI6 chr1 27666064 27672198 - FAM102A chr9 127940582 127980989 - SUMF2 chr7 56064002 56080670 + TAOK1 chr17 29390464 29551904 + MAP7D1 chr1 36155579 36180849 + PSKH1 chr16 67893254 67929676 + TSPAN4 chr11 842812 867116 + GOLGA3 chr12 132768914 132829078 - RAB35 chr12 120095099 120117502 - MPDU1 chr17 7583529 7592789 + THY1 chr11 119417378 119424985 - TSR2 chrX 54440404 54448032 + AP1M1 chr19 16197578 16245907 + ARRDC1 chr9 137605685 137615360 + COQ9 chr16 57447425 57461270 + RMI2 chr16 11249619 11381662 + MEPCE chr7 100428790 100434118 + GBF1 chr10 102245532 102382899 + KRT80 chr12 52168996 52192014 - CAPZB chr1 19338775 19485539 - GRHL2 chr8 101492439 101669726 + RHOB chr2 20447074 20449440 + INO80 chr15 40978880 41116280 - ABAT chr16 8674596 8784575 + B4GALT5 chr20 49632945 49713878 - RCC2 chr1 17406760 17439677 - AKT2 chr19 40230317 40285536 - SMAD7 chr18 48919853 48952052 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC016065.1 chr8 6403551 6407142 - AC016355.1 chr15 67541072 67542604 - AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC069281.2 chr7 100572232 100578700 - AC074117.1 chr2 27356246 27367622 + AC118758.3 chr7 56809214 56848800 - AL022311.1 chr22 37876148 37895563 + AL132655.2 chr20 58817132 58817725 - AP000662.1 chr11 57638024 57652790 + COL4A2-AS2 chr13 110456396 110463287 - GAS5 chr1 173858559 173868882 - LINC00265 chr7 39733430 39793092 + LINC01278 chrX 63222993 63561095 - LINC01772 chr1 16460948 16468481 + MALAT1 chr11 65497688 65506516 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - ZFHX2-AS1 chr14 23511760 23560778 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia