Entry Detail



General Information

Database ID:exR0202738
RNA Name:hsa-miR-512-3p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):53666729End Site(bp):53666750
External Links:hsa-miR-512-3p



Disease Information

Disease Name:Mild Cognitive Impairment
Disease Category:Other Diseases
MeSH ID:D060825
Type:Psychiatry and Psychology Category/Mental Disorders
Alias:Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Mild Cognitive Impairment
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
IFNAR1
chr21
33324429
33359864
+
RAI14
chr5
34656328
34832612
+
NAA16
chr13
41311267
41377030
+
TOB2
chr22
41433494
41446801
-
ASB1
chr2
238426742
238452250
+
RIT1
chr1
155897808
155911404
-
C9orf40
chr9
74946583
74952912
-
STK40
chr1
36339624
36385896
-
LETMD1
chr12
51047962
51060424
+
IQSEC1
chr3
12897043
13283281
-
COQ10B
chr2
197453423
197475308
+
ZCCHC3
chr20
297570
300321
+
FAM120AOS
chr9
93431441
93453581
-
NSD2
chr4
1871393
1982207
+
MTMR12
chr5
32226994
32312987
-
ZNF28
chr19
52797408
52857600
-
WASL
chr7
123681943
123749003
-
TOMM6
chr6
41787662
41789898
+
AP3M1
chr10
74120255
74151063
-
OCRL
chrX
129539849
129592561
+
SYVN1
chr11
65121780
65134533
-
LONP2
chr16
48244300
48363122
+
MID1IP1
chrX
38801432
38806537
+
SBF1
chr22
50445000
50475035
-
TNRC6A
chr16
24610209
24827632
+
RAB31
chr18
9708275
9862551
+
UHRF1BP1
chr6
34792015
34883138
+
ERMP1
chr9
5765076
5833117
-
ATP6V1E1
chr22
17592136
17628749
-
TRIB1
chr8
125430358
125438403
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001731
chr7
100731990
100738448
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001159
chr20
40161688
40179999
-
hsa_circ_0001865
chr9
86292641
86293514
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004687.1
chr17
58330884
58332508
-
AC091564.7
chr11
6610883
6616594
-
AC092718.4
chr16
81030770
81031485
+
FGD5-AS1
chr3
14920347
14948424
-
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia