exRNAdisease

Entry Detail

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General Information

Database ID: exR0202741 RNA Name: hsa-miR-513a-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 147213538 End Site(bp): 147213555 External Links: hsa-miR-513a-5p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AEN chr15 88621337 88632281 + CD276 chr15 73683966 73714514 + FAM168B chr2 131047876 131093460 - GIPC1 chr19 14477760 14496149 - IGF2BP3 chr7 23310209 23470491 - ILF3 chr19 10654261 10692417 + JRK chr8 142657460 142681968 - KCTD21 chr11 78171249 78188626 - KIAA0232 chr4 6781375 6884170 + MET chr7 116672196 116798386 + MTCL1 chr18 8705661 8832778 + NRBP1 chr2 27427790 27442259 + PA2G4 chr12 56104537 56113910 + PAK1 chr11 77321707 77474635 - PLK2 chr5 58453982 58460139 - PPP1CC chr12 110719680 110742939 - PRLR chr5 35048756 35230487 - RHOU chr1 228735479 228746664 + SNX27 chr1 151612006 151699091 + SOX11 chr2 5692384 5701385 + SS18 chr18 26016253 26091217 - STRBP chr9 123109500 123268586 - TMX4 chr20 7977346 8019805 - TXN2 chr22 36467046 36481640 - WASL chr7 123681943 123749003 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000894 chr19 12825634 12826553 - hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC023509.1 chr12 53441741 53467528 + AC095055.1 chr4 151139991 151141103 + AC239868.1 chr1 149861271 149862504 + CYTOR chr2 87454781 87636740 + KCNQ1OT1 chr11 2608328 2699994 - LINC01578 chr15 92819540 92899701 + MIR4435-2HG chr2 111006015 111523376 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG16 chr17 76557764 76565348 + SNHG20 chr17 77086716 77099902 + Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia