Entry Detail



General Information

Database ID:exR0202791
RNA Name:hsa-miR-520a-3p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):53690933End Site(bp):53690954
External Links:hsa-miR-520a-3p



Disease Information

Disease Name:Mild Cognitive Impairment
Disease Category:Other Diseases
MeSH ID:D060825
Type:Psychiatry and Psychology Category/Mental Disorders
Alias:Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Mild Cognitive Impairment
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SEMA3C
chr7
80742538
80922359
-
APP
chr21
25880550
26171128
-
IKZF4
chr12
56007659
56038435
+
MAGI3
chr1
113390515
113685923
+
HTD2
chr3
58306262
58318574
+
RPP14
chr3
58306247
58324695
+
CELF2
chr10
10798397
11336675
+
SLC7A2
chr8
17497088
17570573
+
SYAP1
chrX
16719612
16765340
+
FYCO1
chr3
45917899
45995824
-
PDRG1
chr20
31944337
31952046
-
OCRL
chrX
129539849
129592561
+
CLIP4
chr2
29097705
29189643
+
COL4A2
chr13
110305812
110513209
+
CDK6
chr7
92604921
92836594
-
PLAGL2
chr20
32192504
32207743
-
CLCN6
chr1
11806096
11848079
+
MNT
chr17
2384073
2401104
-
XRRA1
chr11
74807739
74949200
-
ZFAND4
chr10
45615500
45672780
-
CCDC93
chr2
117915478
118014133
-
UCHL1
chr4
41256413
41268455
+
MSL1
chr17
40121971
40136917
+
RACGAP1
chr12
49976923
50033136
-
KIAA1522
chr1
32741830
32774970
+
BTN3A1
chr6
26402237
26415208
+
MBP
chr18
76978827
77133683
-
RGMA
chr15
93035273
93089204
-
CUL1
chr7
148697914
148801110
+
TRIM37
chr17
58982638
59106921
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC125257.1
chr17
41848518
41851447
-
AL049840.4
chr14
103694516
103695050
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
FGD5-AS1
chr3
14920347
14948424
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia