exRNAdisease

Entry Detail

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General Information

Database ID: exR0202793 RNA Name: hsa-miR-520b-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53701267 End Site(bp): 53701287 External Links: hsa-miR-520b-3p

Disease Information

Disease Name: Mild Cognitive Impairment Disease Category: Other Diseases MeSH ID: D060825 Type: Psychiatry and Psychology Category/Mental Disorders Alias: Cognitive Dysfunction//Cognitive Dysfunctions//Dysfunction, Cognitive//Dysfunctions, Cognitive//Cognitive Impairments//Cognitive Impairment//Impairment, Cognitive//Impairments, Cognitive//Mild Cognitive Impairment//Cognitive Impairment, Mild//Cognitive Impairments, Mild//Impairment, Mild Cognitive//Impairments, Mild Cognitive//Mild Cognitive Impairments//Mild Neurocognitive Disorder//Disorder, Mild Neurocognitive//Disorders, Mild Neurocognitive//Mild Neurocognitive Disorders//Neurocognitive Disorder, Mild//Neurocognitive Disorders, Mild//Cognitive Decline//Cognitive Declines//Decline, Cognitive//Declines, Cognitive//Mental Deterioration//Deterioration, Mental//Deteriorations, Mental//Mental Deteriorations

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Mild Cognitive Impairment Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNS1 chr2 217799588 218033982 - CLCN6 chr1 11806096 11848079 + SIRPA chr20 1894167 1940592 + CELF2 chr10 10798397 11336675 + MBP chr18 76978827 77133683 - PLAGL2 chr20 32192504 32207743 - APP chr21 25880550 26171128 - KLHL28 chr14 44924319 45042322 - SEC16A chr9 136440096 136483759 - CCDC93 chr2 117915478 118014133 - MAGI3 chr1 113390515 113685923 + PTP4A1 chr6 63521746 63583436 + SYAP1 chrX 16719612 16765340 + SEMA3C chr7 80742538 80922359 - ADAR chr1 154582057 154628013 - CUL1 chr7 148697914 148801110 + CHD9 chr16 53055033 53329150 + TRIB1 chr8 125430358 125438403 + SLC16A14 chr2 230034982 230068993 - IFNAR1 chr21 33324429 33359864 + WDR82 chr3 52254434 52288020 - RUNDC1 chr17 42980565 42993690 + NPAS2 chr2 100820139 100996829 + JPT1 chr17 75135248 75168281 - LONP2 chr16 48244300 48363122 + OCRL chrX 129539849 129592561 + ZFAND4 chr10 45615500 45672780 - PHC3 chr3 170086732 170181749 - ATXN1 chr6 16299112 16761491 - FAM177A1 chr14 35044907 35113130 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia