Entry Detail



General Information

Database ID:exR0203986
RNA Name:hsa-miR-144-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):28861548End Site(bp):28861567
External Links:hsa-miR-144-3p



Disease Information

Disease Name:Vascular Dementia
Disease Category:Nervous System Diseases
MeSH ID:D015140
Type:Diseases Category/Nervous System Diseases
Alias:Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Vascular Dementia
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANXA2
chr15
60347134
60402883
-
ARHGAP18
chr6
129576132
129710177
-
CNOT11
chr2
101252886
101270316
+
EPHA7
chr6
93240020
93419559
-
G3BP2
chr4
75642782
75724525
-
GABPB1
chr15
50275392
50355408
-
IKZF2
chr2
212999691
213152427
-
RAB15
chr14
64945814
64973226
-
ROCK2
chr2
11179759
11348330
-
SGPP1
chr14
63684216
63728065
-
USP47
chr11
11841423
11961887
+
ZNF695
chr1
246945547
247008093
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001376
chr3
194169185
194175121
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010980.2
chr2
222317242
222318653
-
AC022167.2
chr16
8848105
8860456
+
AC093010.3
chr3
114314501
114329714
-
AF254983.1
chr21
10482738
10605716
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
EBLN3P
chr9
37079645
37090928
+
HCG11
chr6
26521709
26527404
+
LINC00662
chr19
27681072
27794005
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OTUD6B-AS1
chr8
91059318
91070583
-
SDCBP2-AS1
chr20
1325405
1378735
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia