Entry Detail



General Information

Database ID:exR0204473
RNA Name:hsa-miR-3648
RNA Type:miRNA
Chromosome:chr21
Starnd:+
Coordinate:
Start Site(bp):8987026End Site(bp):8987046
External Links:hsa-miR-3648



Disease Information

Disease Name:Vascular Dementia
Disease Category:Nervous System Diseases
MeSH ID:D015140
Type:Diseases Category/Nervous System Diseases
Alias:Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Vascular Dementia
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MT-CO2
chrMT
7586
8269
+
THAP7
chr22
20999104
21002196
-
CERS4
chr19
8206736
8262421
+
ARL8B
chr3
5122245
5180912
+
EEF1G
chr11
62559596
62574086
-
FNBP4
chr11
47716494
47767443
-
PTGES3
chr12
56663341
56688408
-
AP002990.1
chr11
62559603
62591531
-
PTCH2
chr1
44819844
44843253
-
MAPK9
chr5
180233143
180292099
-
ACTG1
chr17
81509971
81523847
-
ECPAS
chr9
111360692
111484745
-
RNF126
chr19
647526
663233
-
SF3A2
chr19
2236824
2248655
+
TPT1
chr13
45333471
45341370
-
AKIRIN2
chr6
87674860
87702233
-
LZTS3
chr20
3162617
3173592
-
AL133352.1
chr10
100505628
100529881
-
ATP6V0A2
chr12
123712353
123761755
+
SET
chr9
128683424
128696400
+
SH3GLB2
chr9
129007036
129028303
-
PAM16
chr16
4331549
4355607
-
LRRC45
chr17
82023305
82031151
+
SRRM2
chr16
2752626
2772538
+
NDUFB8
chr10
100523740
100530000
-
GAPDH
chr12
6534512
6538374
+
CORO7-PAM16
chr16
4340251
4420494
-
SKI
chr1
2228319
2310213
+
SSR2
chr1
156009048
156020951
-
ARRDC4
chr15
97960703
97973833
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia