exRNAdisease

Entry Detail

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General Information

Database ID: exR0204574 RNA Name: hsa-miR-379-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101022071 End Site(bp): 101022091 External Links: hsa-miR-379-5p

Disease Information

Disease Name: Vascular Dementia Disease Category: Nervous System Diseases MeSH ID: D015140 Type: Diseases Category/Nervous System Diseases Alias: Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical

Expression Detail

GEO ID: GSE120584 Description: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Experimental Design: Disease vs Control Case Disease Type: Alzheimer's Disease Case Disease SubType: NA Case Sample: Vascular Dementia Control Sample: Normal Number of Case: 1021 Number of Control: 288 Number of Samples: 1309

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATF7 chr12 53507856 53626410 - CBX5 chr12 54230942 54280133 - CHP1 chr15 41230839 41281887 + DCUN1D4 chr4 51843000 51916837 + EDA2R chrX 66595637 66639298 - MAP3K21 chr1 233327724 233385148 + NONO chrX 71283192 71301168 + NRARP chr9 137299631 137302271 - PLD3 chr19 40348456 40380439 + SIN3A chr15 75369379 75455842 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000741 chr17 7402357 7402810 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand NEAT1 chr11 65422774 65445540 + SCARNA9 chr11 93721513 93721865 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE120584 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2532 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30820472 Title: Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data Author: Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S Journal: Commun Biol. 2019 Feb 25;2:77. Description: we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia