Entry Detail



General Information

Database ID:exR0204652
RNA Name:hsa-miR-425-5p
RNA Type:miRNA
Chromosome:chr3
Starnd:-
Coordinate:
Start Site(bp):49020199End Site(bp):49020221
External Links:hsa-miR-425-5p



Disease Information

Disease Name:Vascular Dementia
Disease Category:Nervous System Diseases
MeSH ID:D015140
Type:Diseases Category/Nervous System Diseases
Alias:Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Vascular Dementia
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL2
chr1
179099330
179229684
-
FOXC1
chr6
1609915
1613897
+
SH3PXD2A
chr10
103594027
103855543
-
SHC1
chr1
154962298
154974395
-
SLC16A2
chrX
74421493
74533917
+
TRIM22
chr11
5689697
5737089
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000591
chr15
41961025
41962156
+
hsa_circ_0000987
chr2
30748452
30756180
+
hsa_circ_0001151
chr20
35236117
35236221
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005034.3
chr2
75697583
75697996
+
AC120036.4
chr8
47190772
47193262
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC01184
chr5
127939152
128083172
-
MALAT1
chr11
65497688
65506516
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG7
chr9
136721366
136728184
-
SNHG8
chr4
118278709
118285316
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia