Entry Detail



General Information

Database ID:exR0205339
RNA Name:hsa-miR-524-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):53711017End Site(bp):53711038
External Links:hsa-miR-524-5p



Disease Information

Disease Name:Vascular Dementia
Disease Category:Nervous System Diseases
MeSH ID:D015140
Type:Diseases Category/Nervous System Diseases
Alias:Dementia, Vascular//Dementias, Vascular//Vascular Dementias//Vascular Dementia//Vascular Dementia, Acute Onset//Acute Onset Vascular Dementia//Subcortical Vascular Dementia//Dementia, Subcortical Vascular//Dementias, Subcortical Vascular//Subcortical Vascular Dementias//Vascular Dementia, Subcortical//Vascular Dementias, Subcortical//Arteriosclerotic Dementia//Arteriosclerotic Dementias//Dementia, Arteriosclerotic//Dementias, Arteriosclerotic//Binswanger Disease//Disease, Binswanger//Chronic Progressive Subcortical Encephalopathy//Binswanger Encephalopathy//Leukoencephalopathy, Subcortical//Leukoencephalopathies, Subcortical//Subcortical Leukoencephalopathies//Encephalopathy, Subcortical Arteriosclerotic//Binswanger's Disease//Binswangers Disease//Disease, Binswanger's//Encephalopathy, Subcortical, Chronic Progressive//Subcortical Encephalopathy, Chronic Progressive//Subcortical Leukoencephalopathy//Subcortical Arteriosclerotic Encephalopathy//Arteriosclerotic Encephalopathy, Subcortical//Arteriosclerotic Encephalopathies, Subcortical//Encephalopathies, Subcortical Arteriosclerotic//Subcortical Arteriosclerotic Encephalopathies//Encephalopathy, Binswanger's//Binswanger's Encephalopathy//Encephalopathy, Binswangers//Encephalopathy, Binswanger//Encephalopathy, Chronic Progressive Subcortical



Expression Detail

GEO ID:GSE120584
Description:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Experimental Design:Disease vs Control
Case Disease Type:Alzheimer's Disease
Case Disease SubType:NA
Case Sample:Vascular Dementia
Control Sample:Normal
Number of Case:1021
Number of Control:288
Number of Samples:1309





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KLHL28
chr14
44924319
45042322
-
NEDD4
chr15
55826922
55993746
-
NR4A2
chr2
156324437
156342348
-
PKN2
chr1
88684222
88836255
+
SIK2
chr11
111602449
111730855
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000095
chr1
95609446
95616975
+
hsa_circ_0000284
chr11
33307958
33309057
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008738.7
chr19
33207129
33207639
+
AC009022.1
chr16
69976297
70065948
-
AC021078.1
chr5
149494314
149504670
-
AC024940.6
chr12
31280422
31280895
-
AC068768.1
chr12
123262060
123262402
+
AC125257.1
chr17
41848518
41851447
-
AC239868.1
chr1
149861271
149862504
+
AL031595.3
chr22
44139365
44153626
+
AL137129.1
chr14
61734138
61776260
+
FGD5-AS1
chr3
14920347
14948424
-
GAS5
chr1
173858559
173868882
-
MCM3AP-AS1
chr21
46229196
46259390
+
MIR29B2CHG
chr1
207801518
207879115
-
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
PITPNA-AS1
chr17
1516931
1518096
+
SCARNA9
chr11
93721513
93721865
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE120584
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2532
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30820472
Title:Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data
Author:Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S
Journal:Commun Biol. 2019 Feb 25;2:77.
Description:we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia