exRNAdisease

Entry Detail

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General Information

Database ID: exR0231727 RNA Name: hsa-miR-1294 RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 154347153 End Site(bp): 154347174 External Links: hsa-miR-1294

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CYB5R3 chr22 42617840 42649392 - STK40 chr1 36339624 36385896 - EIF4A1 chr17 7572706 7579006 + TRAPPC10 chr21 44012309 44106552 + ABCA1 chr9 104781006 104928155 - POGK chr1 166839447 166856344 + FGFR1 chr8 38400215 38468834 - KMT2A chr11 118436490 118526832 + RAB8A chr19 16111889 16134234 + TEX261 chr2 70985942 70994873 - ANKRD49 chr11 94493979 94499578 + PGRMC1 chrX 119236245 119244466 + PTMS chr12 6765516 6770952 + CRY2 chr11 45847118 45883248 + PTP4A1 chr6 63521746 63583436 + APLP2 chr11 130068147 130144811 + CDKN1B chr12 12715058 12722369 + UBE2G2 chr21 44768580 44801826 - PDPR chr16 70113626 70162537 + AKT2 chr19 40230317 40285536 - RNF157 chr17 76142465 76240493 - ZHX3 chr20 41178448 41317672 - ARHGAP28 chr18 6729718 6915716 + PRRC2B chr9 131373636 131500197 + FYCO1 chr3 45917899 45995824 - ZNF512B chr20 63956704 63969930 - SMAD7 chr18 48919853 48952052 - PDE4DIP chr1 148808181 149048286 + TAGLN2 chr1 159918107 159925732 - NACC1 chr19 13116862 13141147 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000247 chr10 74474868 74475660 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000246 chr10 74468040 74475660 + hsa_circ_0001085 chr2 191765289 191789319 + hsa_circ_0000744 chr17 15968183 15971435 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007161.3 chr7 7640752 8004053 + AC021078.1 chr5 149494314 149504670 - AC022150.4 chr19 52650437 52653284 - AL022311.1 chr22 37876148 37895563 + H19 chr11 1995176 2001470 - LINC00265 chr7 39733430 39793092 + NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.