exRNAdisease

Entry Detail

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General Information

Database ID: exR0231884 RNA Name: hsa-miR-193b-3p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 14304017 End Site(bp): 14304038 External Links: hsa-miR-193b-3p

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFAP1 chr4 7758714 7939926 - ANTXR1 chr2 69013178 69249327 + EHD1 chr11 64851642 64888296 - LASP1 chr17 38869859 38921770 + LUZP1 chr1 23084023 23177808 - NUDT21 chr16 56429133 56452199 - RUSC1 chr1 155320894 155331114 + TSPAN14 chr10 80454166 80533124 + ZBTB5 chr9 37438102 37465450 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001025 chr2 69565029 69565697 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092295.2 chr19 36489649 36491040 + AC135050.6 chr16 31122235 31124064 + AL132780.1 chr14 22929607 22956374 + CYTOR chr2 87454781 87636740 + KCNQ1OT1 chr11 2608328 2699994 - LIMD1-AS1 chr3 45676369 45689200 - LINC01184 chr5 127939152 128083172 - MIR194-2HG chr11 64889560 64893449 - MIR4435-2HG chr2 111006015 111523376 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.