exRNAdisease

Entry Detail

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General Information

Database ID: exR0231898 RNA Name: hsa-miR-198 RNA Type: miRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 120395703 End Site(bp): 120395724 External Links: hsa-miR-198

Disease Information

Disease Name: Benign bone and soft tissue tumor Disease Category: Other Diseases MeSH ID: Type: Alias:

Expression Detail

GEO ID: GSE124158 Description: A serum miRNA classifier diagnoses bone and soft tissue sarcomas across various histological subtypes Experimental Design: Cancer vs Control Case Disease Type: Benign bone and soft tissue tumor Case Disease SubType: NA Case Sample: Benign bone and soft tissue tumor Control Sample: Healthy Number of Case: 339 Number of Control: 275 Number of Samples: 614

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C18orf25 chr18 46173553 46266992 + CGN chr1 151510510 151538692 + CS chr12 56271699 56300391 - FSTL1 chr3 120392293 120450993 - UBE2K chr4 39698109 39782792 + CCDC103 chr17 44899142 44905390 + CLTC chr17 59619689 59696956 + FAM187A chr17 44899712 44905390 + LRRC20 chr10 70298970 70382650 - MAP1B chr5 72107234 72209565 + NECTIN2 chr19 44846175 44889223 + RRP7A chr22 42508344 42519796 - TPGS2 chr18 36777647 36829216 - TUBA1A chr12 49184795 49189080 - ZNF281 chr1 200404940 200410056 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand FTX chrX 73940435 74293574 - Display:

Experiment Detail

GEO ID: GSE124158 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2512 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30898996 Title: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes Author: Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T Journal: Nat Commun. 2019 Mar 21;10(1):1299. Description: we investigated serum miRNA profiles from 1002 patientswith bone and soft tissue tumors representing more than 43 histological subtypes,including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas.